Endocrine Abstracts

Introduction: We report stage IV B cell lymphoma in a patient presenting with adrenal failure and an intraabdominal mass which imaging techniques were suggestive for paraganglioma.Case report: A 71-years-old woman admitted to our emergency clinic with severe fatigue and stupor. She was diagnosed to have primary adrenal failure since serum ACTH was 229 pg/ml and cortisol response to 250 μg co-syntropin was 6.17 μg/dl. In abdominal MRI, bilateral...

Introduction: Anaplastic thyroid carcinomas (ATCs) are sometimes accompanied by well-differentiated carcinomas (WDCs), and ATCs have been speculated to be dedifferentiated from the preexisting or coexisting WDCs. We will present two cases determined with both ATC and papillary thyroid carcinoma (PTC.)Case 1: A 82-year-old woman was investigated due to a painful neck mass. Thyroid function tests were normal. Thyroid ultrasonography revealed isohypoechoic ...

Introduction: Primary hyperparathyroidism (PHPT) is a prevalent endocrinologic disease and the most common cause of hypercalcemia. PHPT usually affects the elderly. PHPT younger than 40 years of age is less frequent. In young patients especially for ones younger than 30 years of age, screening for familial syndromes such as MEN 1 and MEN 2A is recommended. However, in most of the cases genetic tests are negative and evidence for other endocrine components are absent. Herein th...

Introduction: Inferior petrosal sinus sampling (IPSS) is the gold standard test to differentiate Cushing’s disease from ectopic Cushing syndrome. IPSS may cause severe complications; however, overall rates are low. Subarachnoid hemorrhage (SAH) has been rarely reported after IPSS. Here we report a case who developed hypertensive emergency, left 6th cranial nerve palsy, and SAH after IPSS.Case: A sixty-two years-old female patient had a history of h...

Purpose: Patients with acromegaly may have changes in balance due to visual disturbances, musculoskeletal abnormalities and changes in body composition. We aim to compare static and dynamic balances in patients with acromegaly and healthy controls and to evaluate effects of exercise on balance in patients with acromegaly.Methods: Twenty-two patients with acromegaly followed at the Endocrinology Outpatient Clinic of Istanbul University, Cerrahpasa Medical...

Purpose: The authors review the clinical outcomes of patients with hypophysitis.Methods: Medical records of hypophysitis patients who were followed between 2007 and 2018 at Cerrahpasa Medical Faculty were evaluated retrospectively. Clinical, endocrinological, pathological and radiological findings and therapies were assessed.Results: Twenty patients (F/M:12/8) were identified with a mean age at diagnosis of 39.14±17.78 years. ...

IntroductionExtramedullary plasmacytoma (EMP) is a plasma cell neoplasm of extraosseous tissues. Less than 5% of all plasma cell neoplasms develop extramedullary. EMP is most common in the upper respiratory tract and oral cavity. The thyroid gland is one of the extremely rare regions. It is more common in men and the average age at diagnosis is 55. Primary thyroid plasmacytoma is one of the rare thyroid neoplasms. It often manifests as a rapidly growing ...

Purpose: Acromegalic patients carry a high burden of cardiovascular, metabolic, and neoplastic diseases, but there are limited studies focusing on morphological and functional changes in the kidneys.Methods: The data of acromegalic patients followed over a 43-year period at our center were examined for the development of chronic kidney disease (CKD), renal cysts, and urological cancers.Results: A total of 394 patients (202M/192F, m...

The co-occurrence of congenital adrenal hyperplasia and type 1 diabetes mellitus (T1DM) is a rare phenomenon in existing literature. The primary cause of congenital adrenal hyperplasia (CAH) is often 21-hydroxylase deficiency (21OHD), a condition associated with the CYP21A2 gene located on chromosome 6p21.3 within the major human leukocyte antigen (HLA) histocompatibility locus. Various gene polymorphisms, particularly in HLA-DQalpha, DQbeta, and DR genes on chromosome 6p21.32...

Introduction: The prevalence of diabetes mellitus (DM) continues to increase worldwide. Diabetic retinopathy (DRP) is one of the most common complications of Type 2 DM. Recently, the effect of thyroid hormones on diabetic microvascular complications has gained much attention. This relationship is explained by the important effects of thyroid hormones on endothelial function. There are studies investigating the relationship between TSH and diabetic nephropathy and DRP. There ar...